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IL-17A-induced mesenchymal stem cells have promising therapeutic value for clinical translation

Kisha Nandini Sivanathan1, Patrick Toby Coates2

  • 1School of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.

Kidney International
|March 25, 2018
PubMed

Interferon (IFN) gamma is the prototypic proinflammatory cytokine used to preactivate the immunomodulatory properties of mesenchymal stem cells (MSC). IFN-gamma, however, converts MSC into a cell therapy that can be immunogenic, detrimental, and hence nonfeasible for clinical application. The article by Bai et al. is an in vivo proof-of-concept study that interleukin-17A (IL-17A) enhances the immunosuppressive, tolerance-promoting, and renoprotective properties of MSC. IL-17A is an alternative cytokine to preactivate MSC. IL-17A enhances the therapeutic efficacy of MSC for renal diseases.

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