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Related Experiment Video

Updated: Feb 12, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Chest CT texture analysis for response assessment in systemic sclerosis.

C Kloth1, J Henes2, T Xenitidis2

  • 1Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm Germany.

European Journal of Radiology
|March 25, 2018
PubMed
Summary

CT-textural features show promise in monitoring lung involvement in systemic sclerosis (SSc) patients post-autologous stem cell transplantation (SCT). These quantitative imaging markers complement traditional assessments, offering insights into therapy-induced pulmonary changes.

Keywords:
Autologous transplantationFibrosisLungStem cell transplantationSystemic sclerosis

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Area of Science:

  • Radiology
  • Pulmonary Medicine
  • Immunology

Background:

  • Systemic sclerosis (SSc) can lead to significant lung involvement.
  • Autologous stem cell transplantation (SCT) is a therapeutic option for severe SSc.
  • Monitoring pulmonary changes post-SCT is crucial for assessing treatment efficacy.

Purpose of the Study:

  • To evaluate CT-textural features for monitoring lung involvement in SSc patients undergoing SCT.
  • To compare CT-textural features with semi-quantitative chest CT, pulmonary function tests (PFT), and clinical parameters (mRSS).

Main Methods:

  • Retrospective analysis of 23 SSc patients who underwent chest CTs before, and 6 and 12 months post-SCT.
  • Response to therapy defined by >10% improvement in FVC and DLCOSB at 6 months.
  • CT-texture analysis (CTTA) including mean, entropy, and uniformity was performed.

Main Results:

  • PFT classified patients into responders (78%) and non-responders (22%).
  • Responders showed significant improvement in mRSS and CTTA parameters at 6 and 12 months post-SCT.
  • Non-responders exhibited increased fibrosis scores and distinct CTTA patterns at baseline.

Conclusions:

  • CT-textural features correlate with visual CT evaluation of SSc-related lung abnormalities.
  • CTTA provides complementary information on therapy-induced structural pulmonary changes post-SCT.
  • Quantitative CT analysis aids in monitoring treatment response and disease progression in SSc lung involvement.