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Central congenital hypothyroidism caused by maternal thyrotoxicosis
Daphne Peeters1,2, Sandra van Gijlswijk3, Ralph W Leunissen1
1Department of Pediatrics, Haaglanden Medisch Centrum (HMC), The Hague, The Netherlands.
Abstract:
Central congenital hypothyroidism (CCH) is a rare and underdiagnosed disease that sometimes is caused by maternal Graves' disease. We report a case of CCH caused by undiagnosed, initially antibody-negative maternal thyrotoxicosis with possible disruption of fetal hypothalamic-pituitary-thyroid axis maturation. In CCH, maternal thyroid disease should be considered.
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