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Cerebral Perforating Artery Disease : Characteristics on High-Resolution Magnetic Resonance Imaging

Jianye Liang1, Yiyong Liu1, Xiaoshuang Xu1

  • 1Medical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, China.

Clinical Neuroradiology
|March 25, 2018
PubMed

Insights

High-resolution MRI effectively visualizes tiny cerebral arteries, aiding stroke cause detection. Reduced lenticulostriate arteries correlate with specific infarct patterns, improving stroke mechanism understanding.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Cerebral perforating arteries are crucial for brain function.
  • Lenticulostriate artery (LSA) territory infarctions are common stroke types.
  • Understanding the anatomical basis of these strokes is vital.

Purpose of the Study:

  • To assess high-resolution magnetic resonance imaging (HR-MRI) feasibility for visualizing normal cerebral perforating arteries.
  • To evaluate HR-MRI's value in identifying causes of LSA territory infarctions.

Main Methods:

  • 31 healthy subjects and 28 patients with LSA infarctions were scanned using a 3-Tesla MRI.
  • Techniques included T1WI, T2WI, DWI, 3D time-of-flight MR angiography (3D-TOF-MRA), and 3D fast spin-echo T1WI (CUBE T1).
  • Two physicians independently confirmed perforating artery numbers and routes on HR-MRI.

Main Results:

  • HR-MRI visualized key perforating arteries, including the recurrent artery of Heubner (RAH) and LSAs.
  • Patients with LSA infarctions showed significantly fewer LSAs on the affected side compared to healthy subjects.
  • Abnormalities in RAH and LSA were linked to specific infarct patterns (centrum semiovale and corona radiata, respectively).

Conclusions:

  • HR 3D-TOF-MRA and CUBE T1 offer unique advantages for in vivo visualization of small cerebral arteries.
  • Recognizing perforating artery abnormalities and associated infarct patterns enhances understanding of LSA infarction mechanisms.
Abstract

Keywords:
Fast spin-echoInfarct patternLenticulostriate infarctionMagnetic resonance angiographyStroke mechanism

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