Modeling autism in non-human primates: Opportunities and challenges

Area of Science:

• Neuroscience
• Genetics
• Developmental Disorders

Background:

• Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by social and behavioral challenges.
• Rodent models have been primary tools for ASD research but face translational limitations due to evolutionary differences.
• Recent advancements include genome manipulation in non-human primates for ASD modeling.

Purpose of the Study:

• To review the progress in developing non-human primate models for ASD research.
• To discuss the challenges and key issues in creating and utilizing these models.
• To highlight opportunities for ASD drug development using primate models.

Main Methods:

• Review of current literature on genome manipulation techniques (lentivirus, TALEN, CRISPR/Cas9) in non-human primates.
• Characterization of established genetically modified non-human primate models for ASD.
• Analysis of the translational value and limitations of existing ASD models.

Main Results:

• Genetically modified non-human primate models for ASD have been successfully produced and characterized.
• These models demonstrate feasibility and offer significant opportunities for ASD research.
• Challenges remain in their development and application for drug discovery.

Conclusions:

• Non-human primate models represent a promising advancement for studying ASD mechanisms.
• Addressing current challenges is essential for maximizing the potential of these models.
• Further development is critical for effective ASD research and therapeutic interventions.