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Updated: Feb 12, 2026

Simple and Efficient Technique for the Preparation of Testicular Cell Suspensions
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Simple and Efficient Technique for the Preparation of Testicular Cell Suspensions

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Capsaicin protects against testicular torsion injury through mTOR-dependent mechanism

Nasim Javdan1, Seyed Abdulmajid Ayatollahi2, Muhammad Iqbal Choudhary3

  • 1ShahidBeheshti University of Medical Sciences, Phytochemistry Research Center, Tehran, Iran.

Theriogenology
|March 25, 2018
PubMed
Abstract

Insights

Testicular torsion causes infertility due to oxidative stress. Capsaicin, an antioxidant, was found to reduce cell death and preserve testicular tissue by inhibiting mTOR phosphorylation.

Area of Science:

  • Reproductive Medicine
  • Cell Biology
  • Pharmacology

Background:

  • Testicular torsion leads to infertility through oxidative stress and apoptosis.
  • Reactive oxygen species (ROS) play a critical role in testicular damage.
  • Capsaicin exhibits anti-inflammatory and antioxidant properties.

Purpose of the Study:

  • To investigate the role of mammalian target of rapamycin (mTOR) in the antioxidant effects of capsaicin.
  • To evaluate capsaicin's efficacy in mitigating reperfusion injury following testicular torsion.

Main Methods:

  • Male Wistar rats were divided into sham, torsion, and capsaicin-treated groups.
  • Western blotting was used to assess anti-apoptotic effects.
  • Histological (H&E) and TUNEL assays evaluated testicular morphology and apoptosis.

Main Results:

  • Testicular torsion significantly increased mTOR phosphorylation.
  • Capsaicin administration, particularly at higher doses, decreased mTOR phosphorylation.
  • Capsaicin treatment preserved tubular morphology and reduced apoptosis in testicular tissue.

Conclusions:

  • Capsaicin's antioxidant properties effectively minimize cell death and reperfusion injury.
  • The study highlights capsaicin's potential therapeutic role in managing testicular torsion complications.
Keywords:
ApoptosisCapsaicinCell survivalTesticular torsionmTOR pathway

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