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Updated: Feb 12, 2026

Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery
Published on: March 4, 2021
Retinal toxicity due to canthaxanthin. Case series
C F Challiol1, A Bastien1, J M Giambruni1
1Departamento de Oftalmología, Hospital Italiano de Buenos Aires, , Buenos Aires, Argentina.
Introduction:
Canthaxanthin is a chemical product used to tan the skin. Its most frequent adverse effect is canthaxanthin retinopathy.
Purpose/ Methods:
Report, case series.
Results:
Two female patients, one 42 years-old and the other 72 years-old, with signs of retinopathy due to canthaxanthin. Complete ophthalmology examinations were carried out. The peripheral fovea birefringent deposits with internal retinal involvement were studied using multimodal imaging.
Conclusion:
Canthaxanthin retinopathy is rare. Multimodal imaging may provide important data for the differential diagnosis of crystalline retinopathy.
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