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Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery
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Retinal toxicity due to canthaxanthin. Case series.

C F Challiol1, A Bastien1, J M Giambruni1

  • 1Departamento de Oftalmología, Hospital Italiano de Buenos Aires, , Buenos Aires, Argentina.

Archivos De La Sociedad Espanola De Oftalmologia
|March 26, 2018
PubMed
Summary

Canthaxanthin retinopathy, a rare condition from skin tanning products, presents with crystalline deposits in the retina. Multimodal imaging aids in diagnosing this adverse effect.

Keywords:
CantaxantinaCanthaxanthinRetinopathyRetinopatíaToxicidadToxicity

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Area of Science:

  • Ophthalmology
  • Toxicology

Background:

  • Canthaxanthin is a synthetic carotenoid used for skin tanning.
  • The most common adverse effect of canthaxanthin is retinopathy.
  • Canthaxanthin retinopathy is characterized by crystalline deposits within the retinal layers.

Purpose of the Study:

  • To report and characterize canthaxanthin retinopathy in two patients.
  • To investigate the utility of multimodal imaging in diagnosing this condition.

Main Methods:

  • Case series involving two female patients (42 and 72 years old) with suspected canthaxanthin retinopathy.
  • Comprehensive ophthalmological examinations.
  • Multimodal imaging techniques to study retinal deposits.

Main Results:

  • Both patients exhibited signs of canthaxanthin retinopathy.
  • Multimodal imaging revealed peripheral foveal birefringent deposits with internal retinal involvement.
  • Detailed imaging data provided insights into the nature of the crystalline deposits.

Conclusions:

  • Canthaxanthin retinopathy is an uncommon but significant adverse effect.
  • Multimodal imaging is a valuable tool for the differential diagnosis of crystalline retinopathy, including canthaxanthin-induced cases.