Related Experiment Video

Updated: Feb 12, 2026

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis
07:47

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Published on: June 26, 2016

10.2K

SIRT1 and microRNAs: The role in breast, lung and prostate cancers

Hedyieh Karbasforooshan1, Ali Roohbakhsh2, Gholamreza Karimi2

  • 1Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Experimental Cell Research
|March 26, 2018
PubMed

Insights

MicroRNAs and SIRT1 play crucial roles in breast, prostate, and lung cancers. Understanding their complex interactions offers new therapeutic strategies for these widespread diseases.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • Breast, prostate, and lung cancers are leading causes of mortality worldwide, necessitating improved treatment strategies due to chemotherapy limitations.
  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and are implicated in cancer development.
  • Sirtuins, specifically SIRT1, are histone deacetylases involved in tumorigenesis through various cellular processes, acting as either oncogenes or tumor suppressors.

Purpose of the Study:

  • To review the specific mechanisms by which microRNAs and SIRT1 pathways influence the development of breast, prostate, and lung cancers.
  • To elucidate the dual role of microRNAs and SIRT1 as either tumor suppressors or promoters based on specific oncogenic pathways.
  • To highlight the potential of targeting microRNA/SIRT1 interactions for novel cancer therapies.

Main Methods:

  • Literature review focusing on the molecular mechanisms of microRNA and SIRT1 involvement in cancer.
  • Analysis of studies detailing how microRNAs target SIRT1 in various cancer types.
  • Synthesis of information on the regulatory roles of microRNAs and SIRT1 in tumorigenesis.

Main Results:

  • MiRNA deregulation is a significant factor in cancer initiation and progression.
  • SIRT1 can function as an oncogene, promoting tumorigenesis through anti-apoptotic activities and influencing cellular processes like proliferation and senescence.
  • MicroRNAs modulate cancer development by directly targeting SIRT1, influencing its oncogenic or tumor-suppressive functions.

Conclusions:

  • The interplay between microRNAs and SIRT1 is critical in the pathogenesis of major cancers, including breast, prostate, and lung cancer.
  • Targeting the microRNA/SIRT1 axis presents a promising avenue for developing more effective cancer treatments.
  • Further research into these specific pathways could lead to personalized therapeutic approaches for cancer patients.
Keywords:
AutophagyCancerMicroRNAsSIRT1Senescence

More Related Videos

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.7K
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

19.0K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.1K
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
2.2K
The Role of Culture01:23

The Role of Culture

Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
440
Role-Based Identity01:21

Role-Based Identity

Role-based identities are central to understanding how individuals navigate social environments by adopting distinct self-conceptions aligned with various societal roles. These identities are not fixed traits but are constructed through personal actions and the social feedback individuals receive in context-specific interactions. Each social role, such as student, teacher, or friend, carries a set of expectations and norms that influence how people think, feel, and behave within that...
220