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A cohort study reporting normal oximetry values in healthy infants under 4 months of age using Masimo technology

Hazel J Evans1, Anne S Karunatilleke2, Sarah Grantham-Hill1,2

  • 1Department of Respiratory Paediatrics, Southampton Children's Hospital, Southampton University Hospital NHS Foundation Trust, Southampton, Hampshire, UK.

Archives of Disease in Childhood
|March 26, 2018
PubMed

Insights

Infant sleep saturation indices, including desaturation index >4% (DI4), are significantly higher in newborns but decrease by 3-4 months. These indices remain elevated compared to older children, indicating ongoing physiological differences in oxygenation.

Area of Science:

  • Pediatric Pulmonology
  • Neonatal Physiology
  • Sleep Medicine

Background:

  • Establishing normative sleep oxygen saturation indices in healthy infants is crucial for accurate clinical assessment.
  • Modern pulse oximetry with motion artifact extraction offers improved data reliability.

Purpose of the Study:

  • To determine normative sleeping saturation indices in healthy term infants using advanced pulse oximetry.
  • To assess changes in these indices from 1 month to 3-4 months of age.

Main Methods:

  • Prospective cohort study involving healthy term infants monitored via nocturnal home pulse oximetry.
  • Data collected at 1 month and 3-4 months of age, with sleep times documented by parents.
  • Visi-Download software used for analysis, excluding artifact and wake periods.

Main Results:

  • Mean saturation index (SAT50) was 97.05% at 1 month and 97.65% at 3-4 months.
  • Desaturation index >4% (DI4) decreased from 16.16 at 1 month to 8.12 at 3-4 months (P=0.006).
  • Significant improvements observed in DI4, DI3, DI12s, and time below 90%/92% saturation by 3-4 months.

Conclusions:

  • Young infants exhibit substantially higher desaturation indices than older children.
  • These indices decrease significantly by 3-4 months of age but remain elevated.
  • Findings highlight age-specific normative values for infant oxygen saturation monitoring.
Abstract

Keywords:
respiratory

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