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Short Communication: Characterization of a New HIV-1 Group N Isolate Originating from a Cameroonian Patient
Paul Alain Tagnouokam Ngoupo1,2, Serge Alain Sadeuh-Mba1, Fabienne De Oliveira2
11 Virology Department, Centre Pasteur of Cameroon , Yaounde, Cameroon .
Abstract:
HIV-1 group N (HIV-1/N) remains rare and mainly restricted to Cameroon. In this study, we report a new HIV-1/N infected case identified during routine HIV screening activities in Yaounde. The genetic characterization of the near full-length genome of this virus strain revealed that it is genetically distinct to all HIV-1/N described to date. However, the Vpu protein responsible for tetherin antagonism displayed the same amino acid substitutions (E15A, V19A, I25L, and V26L) as other HIV-1/N from Cameroon.
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