Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K
Protein-protein Interfaces02:04

Protein-protein Interfaces

14.8K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.8K
Protein and Protein Structure02:15

Protein and Protein Structure

88.9K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
88.9K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

14.7K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.7K
What are Proteins?01:55

What are Proteins?

240.4K
Overview
240.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preparation and Characterization of PVA/PVP/CS Bionic Hydrogels.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

A Multifunctional Fe-EGCG@RSL3 Nanomedicine Synergizes Ferroptosis Induction and Tumor Microenvironment Remodeling for Enhanced Bladder Cancer Immunotherapy.

Research (Washington, D.C.)·2025
Same author

Engineering CRISPR System-Based Bacterial Outer Membrane Vesicle Potentiates T Cell Immunity for Enhanced Cancer Immunotherapy.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

Safety and efficacy of alcohol-mediated bilateral adrenal artery embolization in patients with idiopathic hyperaldosteronism: a 6-month follow-up of a randomized controlled trial.

Journal of human hypertension·2025
Same author

Construction of vascularized liver microtissues recapitulates angiocrine-mediated hepatocytes maturation and enhances therapeutic efficacy for acute liver failure.

Bioactive materials·2025
Same author

Failure Mechanism of Zonal Isolation for Cement Sheath Induced by Density Reduction Operations after Liner Casing Cementing.

ACS omega·2025

Related Experiment Video

Updated: Feb 12, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials
08:55

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials

Published on: June 25, 2018

8.5K

[Progress in the effect of polyamines on proteins].

Lingya Zhang1, Sen Liu1,2

  • 1Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Medical Science, Three Gorges University, Yichang 443002, Hubei, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|March 27, 2018
PubMed
Summary

Polyamines, crucial molecules in all organisms, influence cell growth by interacting with proteins. This review explores polyamine-protein interactions, their impact on protein function, and therapeutic applications.

Keywords:
interactionpolyamineprotein functionprotein structure

More Related Videos

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice
11:16

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Published on: May 3, 2012

22.8K
Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis
10:56

Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis

Published on: August 1, 2019

8.8K

Related Experiment Videos

Last Updated: Feb 12, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials
08:55

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials

Published on: June 25, 2018

8.5K
Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice
11:16

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Published on: May 3, 2012

22.8K
Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis
10:56

Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis

Published on: August 1, 2019

8.8K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Polyamines are ubiquitous aliphatic amines essential for cellular functions.
  • While their effects on nucleic acids are well-documented, polyamine impacts on proteins remain less understood.
  • Proteins are vital macromolecules involved in virtually all cellular processes.

Purpose of the Study:

  • To review current knowledge on how polyamines affect protein structure and function.
  • To discuss the mechanisms of polyamine-protein interactions.
  • To highlight challenges and potential therapeutic applications of studying these interactions.

Main Methods:

  • Literature review of recent research on polyamine-protein interactions.
  • Analysis of studies investigating polyamine effects on various protein types.
  • Discussion of experimental challenges and future directions.

Main Results:

  • Polyamines modulate the function of diverse proteins, including metabolic enzymes and ion channels.
  • Ionic interactions and hydrogen bonds mediate polyamine-protein binding.
  • Understanding these interactions is crucial for comprehending cellular regulation.

Conclusions:

  • Polyamines significantly influence protein function, impacting cellular processes.
  • Further research is needed to fully elucidate polyamine-protein interactions and their therapeutic potential.
  • Targeting polyamine-protein interactions may offer novel strategies for disease treatment.