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Updated: Feb 12, 2026

In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane
Published on: November 28, 2019
Role of FcαR EC2 region in extracellular membrane localization
Ser-Xian Phua1,2, Wai-Heng Lua1, Samuel Ken-En Gan1,3
1a Bioinformatics Institute , Agency for Science, Technology and Research (A*STAR) , Singapore.
Abstract:
The FcαR receptor (CD89) binds to the constant region of Immunoglobulin (Ig) A to mediate mucosal immunity [1-2]. FcαR consist of five exons: two that code for the signal peptide regions S1 & S2, two for the extracellular regions EC1 and EC2, and the final exon for the transmembrane/cytoplasmic tail region [3]. Previously, we reported that the EC1 region plays an essential role for extracellular membrane localization of the receptor [4], where the absence of EC1 would prevent the variants from localizing to the cell surface, even with a full signal peptide. In the case of FcαR Variant 4 (lacking the S2 region only), there was some "leakiness" to membrane surface localization.
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