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Updated: Feb 12, 2026

Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes
Published on: March 9, 2019
Electrophysiological characterization of a mitochondrial inner membrane chloride channel in rat brain
Christopher D Drummond-Main1,2, Jong M Rho1,2,3,4
1Developmental Neurosciences Research Program, University of Calgary, Alberta, Canada.
Abstract:
Mitochondria are an essential component of cellular integrity and homeostasis, and their functions and pathological processes are highly dependent on mitochondrial ion channels. Anion channels of the inner mitochondrial membrane have been described by direct patch-clamp electrophysiological methods in mitoplasts prepared in cardiac, liver, and brown adipose tissue, but not in brain. Here, using acutely isolated rat brain mitoplasts, we describe the properties of a large conductance, voltage-gated, pH-sensitive, outwardly rectifying chloride channel with conductances of 98 pS and 129 pS at negative and positive membrane potentials, respectively. While the molecular identity of this chloride conductance is unknown, it is unlikely to be a CLIC channel due to differences in the observed electrophysiological properties.
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