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Related Experiment Video

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Epigenetic modulation as a therapy in systemic sclerosis.

Steven O'Reilly1

  • 1Faculty of Health and Life Sciences, Northumbria University, Newcastle Upon-Tyne, UK.

Rheumatology (Oxford, England)
|March 27, 2018
PubMed
Summary

Epigenetic modifications regulate myofibroblasts in systemic sclerosis (SSc). Targeting these epigenetic regulators offers a promising new therapeutic strategy for SSc treatment.

Area of Science:

  • Immunology
  • Cell Biology
  • Epigenetics

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease characterized by inflammation and fibrosis.
  • Myofibroblasts are key cells that drive fibrosis by secreting extracellular matrix, leading to tissue stiffening, primarily in skin and lungs.

Purpose of the Study:

  • To review the role of epigenetic modifications in the development of myofibroblasts in SSc.
  • To explore potential therapeutic strategies targeting epigenetic regulators in SSc.

Main Methods:

  • This review examines existing literature on epigenetic mechanisms in SSc.
  • Focuses on the regulation of myofibroblast differentiation and function.

Main Results:

  • Epigenetic modifications, including DNA methylation and non-coding RNAs, are increasingly recognized as crucial in SSc pathogenesis.

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  • These modifications influence myofibroblast activation and extracellular matrix deposition.
  • Cytokines and hormones can modulate these epigenetic changes.

    • Conclusions:

    • Epigenetic dysregulation plays a significant role in SSc.
    • Targeting epigenetic pathways, such as with miRNA replacements, presents a novel therapeutic avenue for SSc.