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A System for Culturing Iris Pigment Epithelial Cells to Study Lens Regeneration in Newt
Published on: June 22, 2011
Diverse Evolutionary Origins and Mechanisms of Lens Regeneration
Jonathan J Henry1, Paul W Hamilton2
1Department of Cell and Developmental Biology, University of Illinois, Urbana, IL.
Abstract:
In this review, we compare and contrast the three different forms of vertebrate lens regeneration: Wolffian lens regeneration, cornea-lens regeneration, and lens regeneration from lens epithelial cells. An examination of the diverse cellular origins of these lenses, their unique phylogenetic distribution, and the underlying molecular mechanisms, suggests that these different forms of lens regeneration evolved independently and utilize neither conserved nor convergent mechanisms to regulate these processes.
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