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Updated: Feb 12, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
Published on: January 25, 2015
Obstacles to improving outcomes in the treatment of uveal melanoma
Katy K Tsai1, Kathryn B Bollin2, Sapna P Patel3
1Cutaneous Oncology, Hellen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
Abstract:
The rate of advances in uveal melanoma has not kept pace with the rate of advances in cutaneous melanoma. Many patients lack access to or knowledge of specialty centers, and integrated multidisciplinary care between ophthalmology, radiation oncology, and medical oncology is far from the norm. This treatment isolation leads to limited communication about novel clinical trial opportunities. Clinical trials themselves are not widely available, and a lack of robust funding limits rapid and complete investigations. This review outlines the obstacles to success in uveal melanoma management and highlights strategies for overcoming these challenges. Cancer 2018;124:2693-2703. © 2018 American Cancer Society.
Insights
Advances in uveal melanoma treatment lag behind cutaneous melanoma due to limited access to specialized centers and multidisciplinary care. Overcoming these obstacles is crucial for improving patient outcomes and clinical trial participation.
Area of Science:
- Ophthalmology
- Oncology
- Medical Research
Background:
- Uveal melanoma treatment advances lag significantly behind cutaneous melanoma.
- Patients often face barriers accessing specialized centers and multidisciplinary care.
- Integrated care among ophthalmology, radiation oncology, and medical oncology is not standard practice.
Purpose of the Study:
- To review the obstacles hindering progress in uveal melanoma management.
- To highlight strategies for overcoming these challenges in uveal melanoma care.
Main Methods:
- Literature review of current uveal melanoma management strategies.
- Analysis of barriers to specialized care and clinical trial access.
- Identification of potential solutions for integrated multidisciplinary care.
Main Results:
- Limited access to specialty centers and fragmented care impede uveal melanoma treatment.
- Poor communication and lack of robust funding restrict clinical trial availability and investigation.
- Current management strategies are insufficient to match the pace of progress seen in other cancers.
Conclusions:
- Addressing access to care and fostering multidisciplinary collaboration are essential for uveal melanoma.
- Increased funding and improved clinical trial infrastructure are necessary for rapid advancements.
- Implementing proposed strategies can enhance uveal melanoma patient outcomes and research.
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