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Updated: Feb 12, 2026
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Murine Model of Wound Healing
Published on: May 28, 2013
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A Modeling Conundrum: Murine Models for Cutaneous Wound Healing
Sharon Elliot1, Tongyu C Wikramanayake2, Ivan Jozic2
1DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA.
The Journal of Investigative Dermatology
|March 27, 2018
Summary
Standardizing preclinical rat models is crucial for advancing wound healing research. Factors like diabetes duration, sex, and assessment methods significantly impact healing outcomes, improving therapeutic translation.
Area of Science:
- Wound healing research
- Preclinical model development
- Translational medicine
Background:
- Cutaneous wound healing is complex and often impaired in disease states.
- Existing murine models have limitations in translating findings to human conditions.
- There is a critical need for well-defined preclinical models for therapeutic development.
Purpose of the Study:
- To highlight the need for standardization in preclinical murine wound models.
- To investigate the impact of key variables on wound healing outcomes in a rat model.
- To improve the translational utility of preclinical wound healing research.
Main Methods:
- Utilized the streptozotocin-induced diabetes mellitus rat model.
- Assessed the influence of diabetes duration on wound healing.
- Evaluated the effects of animal sex and assessment methods on healing outcomes.
Main Results:
- Demonstrated that diabetes duration significantly impacts wound healing in rats.
- Showcased variations in healing based on animal sex and chosen assessment methods.
- Underscored the variability introduced by different experimental parameters.
Conclusions:
- Standardization of preclinical models, including diabetes duration, sex, and assessment, is essential.
- Understanding model limitations enhances the reliability of experimental results.
- Improved preclinical models will facilitate better translation to human chronic wound treatments.
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