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Fluorescence-guided surgery of cancer: applications, tools and perspectives

Philip S Low1, Sunil Singhal2, Madduri Srinivasarao1

  • 1Department of Chemistry and Institute for Drug Discovery, Purdue University, West Lafayette, IN, United States.

Current Opinion in Chemical Biology
|March 27, 2018
PubMed

Insights

Tumor-targeted fluorescent dyes (TTFDs) help surgeons see hidden cancer, improving patient outcomes. These advanced dyes aid in detecting residual, recurrent, and metastatic cancer, enhancing surgical precision and patient survival rates.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Imaging

Background:

  • Residual cancer after surgery leads to significant patient mortality.
  • Current surgical techniques struggle to detect all malignant tissue.
  • Tumor-targeted fluorescent dyes (TTFDs) offer a potential solution to improve cancer resection.

Purpose of the Study:

  • To evaluate the role of TTFDs in enhancing the detection and resection of malignant tissues.
  • To explore the benefits of TTFDs in various oncological applications, including recurrence detection and lymph node differentiation.
  • To highlight the advancements in TTFD technology, focusing on enzyme-activated and ligand-targeted approaches.

Main Methods:

  • Review of existing literature and clinical trials on TTFDs in cancer surgery.
  • Analysis of TTFD performance in detecting residual, recurrent, and metastatic cancer.
  • Comparison of passively accumulating TTFDs with advanced enzyme-activated and ligand-targeted TTFDs.

Main Results:

  • TTFDs significantly improve the visualization of undetected malignant tissue during surgery.
  • Enhanced detection capabilities include residual disease, recurrent lesions, and lymph node metastasis.
  • TTFDs facilitate accurate cancer staging and preserve healthy tissue during resection.
  • Advanced TTFDs show greater promise in clinical trials compared to passively accumulating agents.

Conclusions:

  • TTFDs are a promising tool for reducing cancer recurrence and improving patient survival.
  • Targeted fluorescent dyes enhance surgical precision, especially in minimally invasive procedures.
  • Enzyme-activated and ligand-targeted TTFDs represent the most effective strategies for clinical application.

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