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Murine Renal Transplantation Procedure
Published on: July 10, 2009
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Changes in Antihypertensive Therapy After Renal Transplantation
F Villanego1, A Moreno1, J Wu1
1Department of Nephrology, Hospital Puerta del Mar, Cadiz, Spain.
Transplantation Proceedings
|March 28, 2018
Summary
Antihypertensive therapy decreased one month post-renal transplant (RT) for peritoneal dialysis patients. Hemodialysis patients required more antihypertensive drugs six months after RT, with calcium channel blockers being most common.
Area of Science:
- Nephrology
- Transplantation Medicine
- Cardiovascular Research
Background:
- Post-transplant hypertension affects 60-90% of renal transplant recipients.
- Hypertension is a key factor in chronic graft dysfunction and impacts patient survival.
Purpose of the Study:
- To compare antihypertensive therapy adjustments after renal transplantation (RT).
- To investigate differences based on pre-transplant renal replacement therapy (RRT) type: hemodialysis (HD) or peritoneal dialysis (PD).
Main Methods:
- Retrospective cohort study including 69 HD patients and 38 PD patients.
- Exclusion criteria: non-essential hypertension, graft renal artery stenosis, active urologic complications, or history of acute graft rejection.
- Analysis of antihypertensive therapy changes in relation to pre-transplant RRT.
Main Results:
- PD patients showed a significant reduction in antihypertensive drugs at 1 month post-RT (P = .001) and a trend at 6 months (P = .06).
- HD patients experienced an increase in antihypertensive drugs at 6 months post-RT (P = .027).
- Calcium channel blocker use increased by 1 month (P = .071) and 6 months (P = .036) post-RT.
Conclusions:
- Antihypertensive therapy was reduced by 1 month post-RT.
- Calcium channel blockers were the predominant drug class, though combination therapy was often necessary.
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