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Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
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Long-Standing Ulcerative Colitis May Trigger a Multilineage Cancerization Field.
Matteo Fassan1, Stefano Brignola1, Giacomo Sarzo2
11 Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy.
International Journal of Surgical Pathology
|March 28, 2018
Summary
Ulcerative colitis (UC) inflammation increases colon cancer risk. A case study reveals UC can lead to both neuroendocrine and conventional adenocarcinoma, supporting a multilineage cancerization field theory.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Longstanding inflammation in ulcerative colitis (UC) is linked to a higher risk of neoplastic transformation in the colon mucosa.
- Understanding the spectrum of UC-associated malignancies is crucial for patient management and early detection.
Observation:
- A rare case of poorly-differentiated neuroendocrine carcinoma coexisting with conventional adenocarcinoma in a patient with ulcerative colitis is presented.
- Detailed clinicopathological features of this complex neoplastic presentation were analyzed.
Findings:
- The co-occurrence of two distinct types of cancer (neuroendocrine and adenocarcinoma) in the context of UC suggests a broader field effect.
- This case supports the hypothesis that ulcerative colitis may act as a 'multilineage cancerization field'.
Implications:
- The findings highlight the aggressive potential of UC-associated neoplasia and the need for vigilant surveillance.
- Recognizing UC as a potential multilineage cancerization field may influence diagnostic approaches and therapeutic strategies for associated cancers.
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