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Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community

Yue Chen1, Shouling Wu2, Wenyu Li1

  • 1Department of cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.

Scientific Reports
|March 28, 2018
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) predicts future premature ventricular contractions (PVCs) in the Chinese population. Elevated hs-CRP is particularly associated with increased PVC risk in men.

Area of Science:

  • Cardiology
  • Biomarkers
  • Epidemiology

Background:

  • Premature ventricular contractions (PVCs) are common arrhythmias.
  • Inflammation, indicated by hs-CRP, is increasingly linked to cardiovascular diseases.
  • Predictive markers for PVCs are crucial for early intervention.

Purpose of the Study:

  • To investigate if hs-CRP predicts future PVC events in a community-based Chinese population.
  • To assess the association between hs-CRP levels and PVC incidence.

Main Methods:

  • A cohort of 60,710 participants was analyzed from a larger population study.
  • High-sensitivity C-reactive protein (hs-CRP) levels were measured at baseline.
  • Cox regression models were used to assess the association between hs-CRP quartiles and PVC incidence over a mean follow-up of 74.9 months.

Main Results:

  • The highest quartile of hs-CRP was associated with a significantly increased risk of PVCs (HR 1.36).
  • This association was more pronounced in males (HR 1.45) but not significant in females.
  • Elevated hs-CRP predicted future PVCs even in participants without prior myocardial infarction or stroke.

Conclusions:

  • Elevated hs-CRP is an independent predictor of future PVC events in the Chinese population.
  • hs-CRP may serve as a valuable biomarker for identifying individuals at higher risk of developing PVCs, especially men.
  • Further research may explore the underlying mechanisms linking inflammation and PVC development.

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