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Published on: February 5, 2020
Antiphospholipid Antibody Induced by Nivolumab
Ahmed Aburahma1, Nour Aljariri Alhesan1, Farah Elounais1
1Hurley Medical Center, Michigan State University, East Lansing, MI, USA.
Abstract:
Nivolumab is a monoclonal antibody against the programmed death protein 1 and is used for patients with advanced melanoma. It is associated with potentially immune-related adverse events, including disorders of the skin, GI tract, and the thyroid; these disorders were successfully treated with prednisone and infliximab. Other immunotherapeutic agents were observed to induce the formation of antiphospholipid antibody (APA) including α-interferon and interleukin-2. We present a case of APA development after the third dose of nivolumab in a 71-year-old male with advanced melanoma. The APA was detected after finding a prolonged aPTT; the lupus anticoagulant assay tested positive. The patient was treated with prednisone but, unfortunately, he expired a few days later.
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