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The Vestibular System01:29

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A Practical Diagnostic Approach to Pediatric Episodic Vestibular Syndrome.

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Genetic contribution to vestibular diseases.

Alvaro Gallego-Martinez1, Juan Manuel Espinosa-Sanchez1,2, Jose Antonio Lopez-Escamez3,4,5

  • 1Otology and Neurotology Group CTS495, Department of Genomic Medicine, Centre for Genomics and Oncological Research-Pfizer/University of Granada/Andalusian Regional Government (GENYO), Avda de la Ilustración, 114, 18016, Granada, Spain.

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|March 28, 2018
PubMed
Summary

Genetic variations, both common and rare, significantly impact vestibular disorders like Meniere disease and motion sickness. Understanding these allelic variants is crucial for diagnosing and treating these complex conditions.

Keywords:
DizzinessGeneticsMeniere diseaseVestibular disordersVestibular migraine

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Area of Science:

  • Genetics
  • Otolaryngology
  • Neuroscience

Background:

  • Vestibular disorders have a significant genetic component, with rare variants linked to familial syndromes.
  • The role of common genetic variants in common and rare vestibular conditions is an emerging area of research.

Purpose of the Study:

  • To review the current understanding of common and rare allelic variants in the human genome contributing to vestibular disorders.
  • To explore the genetic basis of episodic vestibular syndromes, progressive vestibular syndrome, and associated hearing loss.

Main Methods:

  • Literature review of genetic studies on vestibular disorders.
  • Analysis of the role of common and rare variants in disease pathogenesis.
  • Discussion of genomic studies and omic data network analyses.

Main Results:

  • Allelic variation is increasingly recognized as a contributor to various vestibular disorders.
  • Rare variants are implicated in familial vestibular syndromes, while common variants are being investigated for their role in sporadic and common conditions.
  • The genetic architecture of most vestibular disorders remains largely undefined.

Conclusions:

  • Genetic variants play a critical role in the etiology of vestibular disorders.
  • Further genomic research and network analyses are needed to elucidate disease pathways.
  • Personalized treatment strategies for vestibular disorders may be developed through a deeper understanding of genetic factors.