Generalized lymphatic anomaly successfully treated with long-term, low-dose sirolimus
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Updated: Feb 12, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Veronika Dvorakova1, David Rea2, Grainne M O'Regan1
1Department of Pediatric Dermatology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.
Abstract:
Generalized lymphatic anomaly is a rare, complex, lymphatic anomaly generally involving soft tissues, spleen, and bones. It can lead to focal skeletal fragility and pathologic effusions. A recent prospective trial of sirolimus for complicated vascular anomalies showed partial response in seven patients with generalized lymphatic anomaly treated with sirolimus with a target trough level of 10-15 ng/mL for 1 year (Adams et al). We describe successful treatment of generalized lymphatic anomaly with a lower-dose, long-term course of sirolimus.
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