Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.7K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
Nursing Code of Ethics01:29

Nursing Code of Ethics

4.7K
The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
4.7K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

4.7K
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Major adverse cardiovascular events of enzalutamide versus abiraterone in prostate cancer: a retrospective cohort study.

Prostate cancer and prostatic diseases·2023
Same author

A Long-Term Study of Adverse Outcomes Associated With Oral Corticosteroid Use in COPD.

International journal of chronic obstructive pulmonary disease·2023
Same author

Temporal trends in guideline-recommended cardiometabolic testing completeness before initiating immune checkpoint inhibitors: A cohort study.

Journal of internal medicine·2023
Same author

Prognostic value of left atrial reverse remodelling in heart failure with preserved ejection fraction.

Journal of cardiovascular medicine (Hagerstown, Md.)·2023
Same author

Exercise-based cardiac rehabilitation for left ventricular function in patients with heart failure: A systematic review and meta-analysis.

Current problems in cardiology·2023
Same author

Long-term efficacy and safety of cryoballoon ablation of atrial fibrillation: A systematic review and meta-analysis.

Pacing and clinical electrophysiology : PACE·2023
Same journal

Periodontitis-Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine-Mediated Acidosis Adaptation.

Cell proliferation·2026
Same journal

PLIN5 Protects Against Ang II-Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet-Mitochondria Contact.

Cell proliferation·2026
Same journal

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap.

Cell proliferation·2026
Same journal

The E-cadherin-Wnt-mir-994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance.

Cell proliferation·2026
Same journal

A Multicellular Coordinated Network Driving Lymphovascular Space Invasion in Endometrioid Endometrial Carcinoma.

Cell proliferation·2026
Same journal

RETRACTION: Long Non-Coding RNA HCG11 Modulates Glioma Progression Through Cooperating With miR-496/CPEB3 Axis.

Cell proliferation·2026
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.2K

Long non-coding RNAs in melanoma.

Xin Yu1, Heyi Zheng1, Gary Tse2

  • 1Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Cell Proliferation
|March 28, 2018
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) play a key role in melanoma, a lethal skin cancer. This review explores their function and potential for diagnosing, prognosing, and treating melanoma.

Keywords:
SLNCR1UCA1lncRNAprognosis

More Related Videos

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation
10:21

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Published on: February 1, 2019

8.8K
Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
07:24

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

2.7K

Related Experiment Videos

Last Updated: Feb 12, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.2K
Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation
10:21

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Published on: February 1, 2019

8.8K
Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
07:24

Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

Published on: July 9, 2021

2.7K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Melanoma is an aggressive skin cancer with a high metastatic potential.
  • While genetic and epigenetic factors are studied, the role of regulatory non-coding RNAs in melanoma is not well understood.
  • Long non-coding RNAs (lncRNAs) are regulators of gene expression involved in cellular processes like proliferation and migration.

Purpose of the Study:

  • To review the functional roles of lncRNAs in melanoma development and progression.
  • To explore the potential clinical applications of lncRNAs in melanoma diagnosis, prognostication, and treatment.

Main Methods:

  • Literature review of studies on lncRNAs in melanoma.
  • Summary of evidence on the deregulation and function of specific lncRNAs (e.g., HOTAIR, MALAT1, BANCR, ANRIL, SPRY-IT1, SAMMSON) in melanoma.
  • Analysis of current and potential clinical applications.

Main Results:

  • Numerous lncRNAs are deregulated in melanoma.
  • lncRNAs influence key cellular processes critical to melanoma's aggressive phenotype, including proliferation, migration, and invasion.
  • Specific lncRNAs have been identified with roles in melanoma pathogenesis.

Conclusions:

  • lncRNAs are significant regulators in melanoma.
  • lncRNAs hold promise as biomarkers for melanoma diagnosis and prognostication.
  • Targeting lncRNAs may offer novel therapeutic strategies for melanoma treatment.