Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Frequency Response of a Circuit01:20

Frequency Response of a Circuit

805
Inductive circuits present intriguing challenges in electrical engineering, particularly during the transition from the time domain to the frequency domain. This transformation involves converting inductors into impedances and utilizing phasor representation.
The transfer function is pivotal in characterizing how these circuits react to various frequencies, facilitating a profound understanding of their behavior. An essential parameter is the time constant, signifying the...
805
Chronopharmacokinetics: Time-Dependent Pharmacokinetics01:20

Chronopharmacokinetics: Time-Dependent Pharmacokinetics

419
Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
419
The Integrated Rate Law: The Dependence of Concentration on Time02:39

The Integrated Rate Law: The Dependence of Concentration on Time

43.8K
While the differential rate law relates the rate and concentrations of reactants, a second form of rate law called the integrated rate law relates concentrations of reactants and time. Integrated rate laws can be used to determine the amount of reactant or product present after a period of time or to estimate the time required for a reaction to proceed to a certain extent. For example, an integrated rate law helps determine the length of time a radioactive material must be stored for its...
43.8K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

9.5K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
9.5K
Types of Responses of Series RLC Circuits01:11

Types of Responses of Series RLC Circuits

2.0K
A second-order differential equation characterizes a source-free series RLC circuit, marking its distinct mathematical representation. The complete solution of this equation is a blend of two unique solutions, each linked to the circuit's roots expressed in terms of the damping factor and resonant frequency.
2.0K
Frequency Response of Op Amp Circuits01:20

Frequency Response of Op Amp Circuits

726
Operational amplifiers (op-amp) are used in signal conditioning, filtering, or for performing mathematical operations such as addition, subtraction, integration, and differentiation. The frequency response of an op-amp is an important aspect that describes how the gain of the amplifier varies with frequency.
Frequency Response and Gain:
The gain of the op-amp, A(ω), is not a constant but a function of the input signal frequency. An op-amp can maintain a constant gain at low frequencies, known...
726

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-Throughput Screening of Cyanobacterial PHB Production Using Fluorescence-Based Detection.

Microbial biotechnology·2026
Same author

Bacterial Cellulose Membranes Functionalized with In Situ Green-Synthesized Silver Nanoparticles for Antibacterial Applications.

International journal of molecular sciences·2026
Same author

Temperature-Dependent Recombinase-Based Genetic Circuits.

International journal of molecular sciences·2025
Same author

Assessment of Polyhydroxybutyrate Production by Cyanobacteria Strains Isolated from Environmental Water Sources Using a Secondary Effluent.

ACS ES&T water·2025
Same author

Modelling challenges to unlock the power of phototrophic systems for wastewater valorization.

Biotechnology advances·2025
Same author

Intein-mediated thyroid hormone biosensors: towards controlled delivery of hormone therapy.

Frontiers in systems biology·2025
Same journal

Genetic Biosensor for Optimizing Double-Stranded RNA Production by Bacteria.

ACS synthetic biology·2026
Same journal

Heterologous Expression of an Abandoned Termite Mound Fungus Gene Cluster Reveals a Protective Aldehyde-Alcohol Cycle and a Candidate Termiticidal Metabolite.

ACS synthetic biology·2026
Same journal

A Framework for the In Vivo Production of Extensively Engineered Thiopeptides.

ACS synthetic biology·2026
Same journal

A Highly Stringent Split Intein-Mediated DHFR Selectable Marker Enables Efficient Development of High-Producing CHO Cells for Therapeutic Proteins.

ACS synthetic biology·2026
Same journal

Breaking the Stability-Activity-Selectivity Trilemma in Unspecific Peroxygenase through Computation-Based Cross-Regional Combinatorial Mutagenesis.

ACS synthetic biology·2026
Same journal

Sequential Plasmid Curing and Genome Editing in <i>Escherichia coli</i> Nissle 1917.

ACS synthetic biology·2026
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment
08:24

Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment

Published on: June 12, 2016

8.7K

Plug-and-Play Multicellular Circuits with Time-Dependent Dynamic Responses.

Arturo Urrios, Eva Gonzalez-Flo, David Canadell

    ACS Synthetic Biology
    |March 28, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Multicellular architectures offer a novel approach to creating cellular devices for disease treatment, bypassing complex genetic engineering. This study demonstrates their use in regulating glucose levels, paving the way for new diabetes therapies.

    Keywords:
    biological computationdiabetesdynamic responsesmulticellular circuitssynthetic biology

    More Related Videos

    A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles
    12:51

    A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles

    Published on: November 14, 2015

    10.4K
    Time-dependent Increase in the Network Response to the Stimulation of Neuronal Cell Cultures on Micro-electrode Arrays
    10:45

    Time-dependent Increase in the Network Response to the Stimulation of Neuronal Cell Cultures on Micro-electrode Arrays

    Published on: May 29, 2017

    10.3K

    Related Experiment Videos

    Last Updated: Feb 12, 2026

    Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment
    08:24

    Extended Time-lapse Intravital Imaging of Real-time Multicellular Dynamics in the Tumor Microenvironment

    Published on: June 12, 2016

    8.7K
    A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles
    12:51

    A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles

    Published on: November 14, 2015

    10.4K
    Time-dependent Increase in the Network Response to the Stimulation of Neuronal Cell Cultures on Micro-electrode Arrays
    10:45

    Time-dependent Increase in the Network Response to the Stimulation of Neuronal Cell Cultures on Micro-electrode Arrays

    Published on: May 29, 2017

    10.3K

    Area of Science:

    • Synthetic biology
    • Biomedical engineering
    • Cellular engineering

    Background:

    • Synthetic biology aims to create living cellular devices for biomedical applications, offering alternatives to traditional treatments.
    • Complex genetic circuits are often required for cellular devices, posing challenges for physiological implementation.
    • Multicellular architectures are explored as a potential alternative to complex genetic circuits.

    Purpose of the Study:

    • To investigate multicellular architectures as a method for implementing cellular devices.
    • To develop and demonstrate circuits for glucose-responsive insulin or glucagon production.
    • To show that multicellular configurations can tune circuit properties without genetic engineering.

    Main Methods:

    • Exploration of multicellular architectures for cellular device implementation.
    • Design and construction of circuits for insulin/glucagon production based on glucose levels.
    • Utilizing incoherent feed-forward loop (FFL) architectures within multicellular consortia.

    Main Results:

    • Circuit affinity and sensitivity are tunable by altering multicellular consortium configurations.
    • Demonstrated ability to adjust circuits for single pulse responses using FFL architecture.
    • Proof-of-concept for cellular devices regulating glucose-dependent hormone production.

    Conclusions:

    • Multicellular architectures provide a method for tuning cellular device properties without genetic modification.
    • These findings offer a blueprint for developing cellular devices for glycemia regulation in diabetic patients.
    • The study highlights the potential of synthetic biology in creating advanced biomedical solutions.