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Related Experiment Video

Updated: Feb 12, 2026

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Combined Pathologies in FTLD-TDP Types A and C.

Tamar Gefen1,2, Saman S Ahmadian1, Qinwen Mao1,3

  • 1Cognitive Neurology and Alzheimer's Disease Center.

Journal of Neuropathology and Experimental Neurology
|March 28, 2018
PubMed
Summary

Combined pathologies frequently co-occur with frontotemporal lobar degeneration with phosphorylated 43-kDa TAR DNA-binding protein (FTLD-TDP) type-A, influencing lifespan and disease duration. Genetic mutations may impact combined pathology presence and onset age in FTLD-TDP.

Area of Science:

  • Neuroscience
  • Neuropathology
  • Genetics

Background:

  • Frontotemporal lobar degeneration with phosphorylated 43-kDa TAR DNA-binding protein (FTLD-TDP) is a neurodegenerative disease often presenting as primary progressive aphasia or behavioral variant frontotemporal dementia (bvFTD).

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  • The co-occurrence of multiple pathologies in neurodegenerative diseases is increasingly recognized and can influence disease presentation and progression.