Adaptation, Exaptation, and Constraint: A Hormonal Perspective

We approach conceptual issues in evolutionary biology from an endocrinological perspective, noting that single hormones typically act on several target tissues and thereby mediate suites of correlated phenotypic traits. When several components of such a suite are beneficial, an important evolutionary question is whether all are adaptations or some are exaptations. The answer may depend on whether the traits arose in response to selection on variation in systemic levels of the hormone on variation in responsiveness of target tissues to invariant levels of the hormone. If the former, selection probably acted directly on fewer than all traits; beneficial traits arising indirectly would be exaptations. In contrast, multiple beneficial traits that arose out of independent changes in target-tissue sensitivity to invariant hormone levels could all be adaptations. Knowledge of specific hormonal mechanisms as well as of historical selective regimes will be necessary to draw such distinctions. Endocrine constraints on evolution can be studied experimentally by applying hormones systemically and measuring interdependent responses of beneficial and detrimental traits to selection (phenotypic engineering with hormones). Supposing that alteration of one trait in isolation would enhance fitness, cases in which the net effect of endocrine alteration of multiple traits is to depress fitness provide evidence for constraints. We briefly report results of recent studies employing hormonal manipulations, stressing our own work on the dark-eyed junco (Junco hyemalis: Emberizidae).