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Successful Treatment of Persistent Burkholderia cepacia Complex Bacteremia with Ceftazidime-Avibactam
Pranita D Tamma1, Yunfan Fan2, Yehudit Bergman3
1Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA ptamma1@jhmi.edu David.Greenberg@UTSouthwestern.edu.
Abstract:
We report our clinical experience treating a 2-month-old infant with congenital diaphragmatic hernia who experienced prolonged bacteremia with Burkholderia cepacia complex (Bcc) despite conventional antibiotic therapy and appropriate source control measures. The infection resolved after initiation of ceftazidime-avibactam. Whole-genome sequencing revealed that the isolate most closely resembled B. contaminans and identified the mechanism of resistance that likely contributed to clinical cure with this agent. Ceftazidime-avibactam should be considered salvage therapy for Bcc infections if other treatment options have been exhausted.
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