Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Plant Breeding and Biotechnology01:59

Plant Breeding and Biotechnology

21.8K
Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
21.8K
Constraints and Statical Determinacy01:26

Constraints and Statical Determinacy

1.0K
In structural engineering, the equilibrium of a system is not only determined by its equations of equilibrium but also with the help of constraints. Constraints refer to restrictions on the motion of a system. The proper combinations of constraints can minimize the total number of constraints needed to maintain a system in mechanical equilibrium. When this happens, the system is said to be statically determinate. For such systems, the unknown reaction supports can be estimated using equilibrium...
1.0K
Regulation of Food Intake01:30

Regulation of Food Intake

2.9K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.9K
Microbial Morphologies01:29

Microbial Morphologies

4.1K
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
4.1K
Microbial Fermentation01:23

Microbial Fermentation

1.6K
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
1.6K
Microorganisms in Agriculture and Food industry01:27

Microorganisms in Agriculture and Food industry

1.6K
Microorganisms play a crucial role in agriculture and the food industry, contributing to soil fertility, crop protection, and food production. Their functions range from nitrogen fixation and biopesticide production to fermentation and food preservation, making them indispensable to sustainable farming and food safety.Role in AgricultureNitrogen-fixing bacteria, such as Rhizobium (symbiotic) and Azotobacter (free-living), convert atmospheric nitrogen into ammonia through biological nitrogen...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-throughput generation and comparison of genome-scale metabolic models reveal strain-specific metabolic diversity in 439 <i>Lactococcus</i> strains.

mSystems·2026
Same author

Microbial interactions shape cheese flavour formation.

Nature communications·2023
Same author

Development of a Tetracycline-Inducible System for Conditional Gene Expression in Lactococcus lactis and Streptococcus thermophilus.

Microbiology spectrum·2023
Same author

Novel Insights into the Molecular Mechanisms Underlying Robustness and Stability in Probiotic Bifidobacteria.

Applied and environmental microbiology·2023
Same author

Stress Response in Bifidobacteria.

Microbiology and molecular biology reviews : MMBR·2022
Same author

Differential Amino Acid Uptake and Depletion in Mono-Cultures and Co-Cultures of <i>Streptococcus thermophilus</i> and <i>Lactobacillus delbrueckii</i> subsp. <i>bulgaricus</i> in a Novel Semi-Synthetic Medium.

Microorganisms·2022

Related Experiment Video

Updated: Feb 12, 2026

Investigating the Microbial Community in the Termite Hindgut - Interview
21:02

Investigating the Microbial Community in the Termite Hindgut - Interview

Published on: May 28, 2007

11.2K

Constraint-based modeling in microbial food biotechnology.

Martin H Rau1, Ahmad A Zeidan2

  • 1Discovery, R&D Microbial Platform, Chr. Hansen A/S, 2970 Hørsholm, Denmark.

Biochemical Society Transactions
|March 29, 2018
PubMed
Summary

Constraint-based modeling (CBM) analyzes microbial networks, aiding industrial food culture development and bioprocess optimization. This approach enhances strain design and food product innovation by understanding genotype-phenotype relationships.

Keywords:
constraint-based modelingfood fermentationmetabolic networksmicrobial community modelingmicrobial food culturesstrain development

More Related Videos

'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake
04:46

'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake

Published on: September 18, 2018

7.9K
Pyrosequencing for Microbial Identification and Characterization
12:37

Pyrosequencing for Microbial Identification and Characterization

Published on: August 22, 2013

48.0K

Related Experiment Videos

Last Updated: Feb 12, 2026

Investigating the Microbial Community in the Termite Hindgut - Interview
21:02

Investigating the Microbial Community in the Termite Hindgut - Interview

Published on: May 28, 2007

11.2K
'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake
04:46

'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake

Published on: September 18, 2018

7.9K
Pyrosequencing for Microbial Identification and Characterization
12:37

Pyrosequencing for Microbial Identification and Characterization

Published on: August 22, 2013

48.0K

Area of Science:

  • Systems biology
  • Metabolic engineering
  • Food microbiology

Background:

  • Genomics data is rapidly expanding, requiring structured integration with biological knowledge.
  • Genome-scale metabolic network reconstruction provides a framework for this integration.
  • Constraint-based modeling (CBM) is a key analytical tool for these networks.

Purpose of the Study:

  • To highlight the benefits of CBM for industrial food culture production and processing.
  • To demonstrate CBM's role in improving mechanistic understanding of microbial physiology and genotype-phenotype relationships.
  • To showcase CBM's potential in rational strain and culture design for enhanced food products and optimized bioprocesses.

Main Methods:

  • Genome-scale metabolic network reconstruction.
  • Application of constraint-based modeling (CBM) for qualitative and quantitative analyses.
  • Model-guided strain and community design approaches.

Main Results:

  • CBM facilitates understanding of physiology and genotype-phenotype links, essential for strain improvement.
  • CBM aids in designing defined microbial communities for novel food products.
  • CBM enables knowledge-driven optimization of bioprocesses for microbial food cultures.

Conclusions:

  • CBM is a powerful tool for strain development, culture development, and process optimization in food culture production.
  • CBM can drive innovation in food product development through rational design of microbial communities.
  • Awareness of CBM's limitations is crucial for appropriate application and interpretation of model predictions.