Related Experiment Video

Updated: Feb 12, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K

Alcohol Septal Ablation for the Treatment of Hypertrophic Obstructive Cardiomyopathy

Constantinos O'Mahony1, Saidi A Mohiddin1, Charles Knight1

  • 1The Heart Muscle Disease Clinic, London Chest Hospital, London, UK.

Interventional Cardiology (London, England)
|March 29, 2018
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) can cause obstructive symptoms. For drug-refractory cases, alcohol septal ablation (ASA) is a key treatment option to consider for left ventricular outflow tract obstruction (LVOTO).

Area of Science:

  • Cardiology
  • Inherited Cardiovascular Diseases

Background:

  • Hypertrophic cardiomyopathy (HCM) is an inherited heart muscle disease.
  • A subset of HCM patients experience left ventricular outflow tract obstruction (LVOTO), leading to severe symptoms.
  • Current guidelines suggest medical management for symptomatic HCM, escalating to invasive options if refractory.

Purpose of the Study:

  • To provide an overview of HCM and LVOTO pathophysiology.
  • To review the role and efficacy of alcohol septal ablation (ASA) in managing drug-refractory LVOTO in HCM patients.

Main Methods:

  • Literature review focusing on HCM, LVOTO mechanisms, and treatment modalities.
  • Analysis of the application and outcomes of ASA in the context of drug-refractory LVOTO.

Main Results:

  • HCM is characterized by left ventricular hypertrophy.
  • LVOTO can significantly limit patient function and quality of life.
  • ASA presents a viable therapeutic option for carefully selected patients with drug-refractory LVOTO.

Conclusions:

  • Effective management of symptomatic LVOTO in HCM is crucial.
  • Multidisciplinary evaluation is essential for treatment decisions.
  • Alcohol septal ablation (ASA) is an important interventional tool for drug-refractory obstructive hypertrophic cardiomyopathy.

Keywords:
Hypertrophic cardiomyopathyalcohol septal ablationleft ventricular outflow tract obstructionmyectomyoutflow tract obstruction

More Related Videos

Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter08:00

Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter

Published on: June 15, 2015

14.5K
Thermal Ablation for the Treatment of Abdominal Tumors07:16

Thermal Ablation for the Treatment of Abdominal Tumors

Published on: March 7, 2011

35.1K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
526
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
589
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
587
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
470
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
619
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
365