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Updated: Feb 12, 2026

Isolation and Biophysical Study of Fruit Cuticles
Published on: March 30, 2012
New secoiridoids from the fruits of Ligustrum lucidum
Zuo-Cheng Qiu1, Xiao-Xiao Zhao1, Qing-Chang Wu1
1a Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy , Jinan University , Guangzhou 510632 , China.
Abstract:
Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6'-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells.
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