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Updated: Feb 12, 2026
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Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models
Published on: November 21, 2015
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Paneth Cells and their Antimicrobials in Intestinal Immunity
Timon E Adolph1, Lisa Mayr1, Felix Grabherr1
1Department of Internal Medicine I, Gastroenterology, Endocrinology & Metabolism, Medical University Innsbruck, Innsbruck, Austria.
Current Pharmaceutical Design
|March 29, 2018
Summary
Paneth cells are crucial for intestinal homeostasis, producing antimicrobials and regulating stem cells. Disturbances in Paneth cell function are linked to inflammatory bowel diseases, impacting gut health.
Area of Science:
- Gastroenterology
- Immunology
- Cell Biology
Background:
- Paneth cells, identified in 1872, are specialized epithelial cells in the small intestine.
- These cells are vital for maintaining intestinal homeostasis through antimicrobial production and stem cell regulation.
Purpose of the Study:
- To review the current understanding of Paneth cell functions.
- To explore the role of Paneth cells and their antimicrobials in health and disease.
Main Methods:
- Literature review of recent studies on Paneth cells.
- Synthesis of information on Paneth cell roles in homeostasis, microbial control, and stem cell regulation.
Main Results:
- Paneth cells are highly secretory and evolutionarily conserved.
- They produce antimicrobials essential for controlling gut microbiota.
- Paneth cell dysfunction is implicated in intestinal inflammation and susceptibility to infection.
Conclusions:
- Altered Paneth cell function is associated with inflammatory disease models.
- Paneth cell disturbances are linked to human intestinal diseases like Crohn's disease and ulcerative colitis.
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