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Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

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Published on: October 24, 2018

[Extracorporeal photopheresis].

Aurélie Hsieh¹, Begonia Cortés¹

¹Service de dermatologie et vénéréologie, HUG, 1211 Genève 14.

Revue Medicale Suisse

|March 29, 2018

Summary

Extracorporeal photopheresis (ECP) uses ultraviolet light and a photosensitizer to treat various immune conditions. This review covers ECP

Area of Science:

Immunology
Dermatology
Transplantation

Background:

Extracorporeal photopheresis (ECP) is a therapeutic procedure involving ultraviolet A light and 8-methoxypsoralen.
Initially developed for cutaneous T-cell lymphoma, ECP has demonstrated efficacy in other immune-related disorders.
Despite its long-standing use in specialized centers, ECP remains unfamiliar to many physicians.

Purpose of the Study:

To review the practical aspects of performing ECP.
To elucidate the mechanism of action of ECP.
To outline the current clinical indications for ECP.

Main Methods:

Apheresis to collect white blood cells.
Incubation of collected cells with 8-methoxypsoralen.
Exposure of cells to ultraviolet A light.

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Main Results:

ECP shows efficacy in cutaneous T-cell lymphoma.
ECP is effective in managing graft-versus-host disease (acute and chronic).
ECP demonstrates utility in preventing transplant rejection (lung and cardiac) and treating autoimmune diseases.

Conclusions:

ECP is a valuable therapeutic option for various immune-mediated conditions.
Understanding ECP's practicalities, mechanism, and indications is crucial for broader clinical adoption.
Further dissemination of knowledge on ECP can improve patient outcomes in complex immune disorders.