Increased ethanol consumption after interruption of fat bingeing
M Carmen Blanco-Gandía1, José Miñarro1, Maria Asuncion Aguilar1
1Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Valencia, Spain.
Plos One
|March 29, 2018
Summary
Adolescent high-fat bingeing increases alcohol consumption and motivation to obtain alcohol, even after cessation. These findings suggest long-lasting effects of binge eating on the brain's reward system, impacting alcohol vulnerability.
Area of Science:
- Neuroscience
- Behavioral Science
- Addiction Research
Background:
- Comorbidity of alcohol abuse and eating disorders is significant, particularly in adolescents.
- Previous research indicates adolescent high-fat bingeing enhances ethanol's rewarding effects.
Purpose of the Study:
- To investigate if vulnerability to ethanol persists after adolescent high-fat bingeing cessation.
- To assess long-term changes in ethanol consumption and motivation.
Main Methods:
- Adolescent OF1 mice underwent high-fat bingeing.
- Post-cessation testing included ethanol self-administration, conditioned place preference (CPP), and locomotor sensitization.
- Testing occurred 15 days after the last high-fat access.
Main Results:
- Mice showed increased ethanol consumption and motivation to obtain ethanol after cessation.
- Conditioned place preference for ethanol remained unaffected.
- Locomotor response to ethanol was enhanced.
Conclusions:
- Compulsive fat intake during adolescence induces lasting alterations in the reward system.
- These changes contribute to increased ethanol consumption and vulnerability post-cessation.
- Findings highlight the enduring impact of binge eating on alcohol reward pathways.
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