[Milk, Daily products and Bone health.Effect of Milk or Milk Protein on Cognitive Function.]

Increase in milk and dairy intake reduces the development of all-cause dementia, especially Alzheimer's disease(AD)in elderly Japanese population from the Hisayama study. Recent meta-analysis also indicates that beneficial effect of milk and dairy intake on cognitive disorders is significantly observed in Asian population. We have reported that oral administration of milk peptide, CH-3 to AD model mice not only improved cognitive function but also suppressed the expression of inflammatory cytokines and production of oxidative stress. Moreover, administration of other milk proteins improves cognitive function or outcome in AD patients. These findings indicate that milk and dairy intake have possible anti-dementia effects. Further analysis should be necessary to overcome the explosion of dementia worldwide with lifestyle modification.