[Anti-seborrhea effect of cimetidine]

Cimetidine, a histamine H2 antagonist, seems to have anti-androgenic activity. 22 young women were studied during follicular phase prior to and after a 3 month period of treatment with cimetidine (1,200 mg daily). Three month treatment with cimetidine resulted in a significant decrease of seborrheic index (p less than 10(-4)) and casual level (p less than 10(-4)). Testosterone level, TeBG binding capacity and free testosterone were unaffected by the treatment. Cimetidine decrease sebum secretion without change in androgen parameters.