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Updated: Feb 12, 2026
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Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
Published on: March 14, 2014
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Prostate cancer screening: what can we learn from randomised trials?
1Faculty of Social Sciences/Health Sciences, University of Tampere, Tampere, Finland.
Translational Andrology and Urology
|March 30, 2018
Summary
This review evaluates prostate cancer screening trials using randomized trial principles. It summarizes findings, discusses evidence limitations, and identifies future research needs for prostate cancer screening.
Area of Science:
- Urology
- Oncology
- Clinical Trials Methodology
Background:
- Prostate cancer screening remains a topic of significant clinical debate.
- Randomized controlled trials (RCTs) are the gold standard for evaluating screening efficacy.
- Evaluating existing prostate cancer screening trials against established RCT principles is crucial.
Purpose of the Study:
- To describe the core principles of randomized trials.
- To critically assess published prostate cancer screening trials based on these principles.
- To provide a comprehensive summary and evaluation of the current evidence.
Main Methods:
- Literature review of published prostate cancer screening trials.
- Application of established randomized trial design and analysis principles for evaluation.
- Synthesis of findings from evaluated trials.
Main Results:
- Summary of key outcomes from major prostate cancer screening randomized trials.
- Identification of strengths and weaknesses in the methodologies of these trials.
- Assessment of the overall quality of evidence for prostate cancer screening.
Conclusions:
- The current evidence base for prostate cancer screening has notable limitations.
- Further high-quality randomized trials are needed to clarify the benefits and harms.
- Open questions regarding optimal screening strategies and target populations remain.
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