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Plasma IL-1 Receptor Antagonist Concentration Has an Inverse Association With Birth Weight in Prepubertal Children

Henrikki Nordman1, Raimo Voutilainen1, Leena Antikainen1

  • 1Department of Pediatrics, University of Eastern Finland and Kuopio University Hospital, FI-70211 Kuopio, Finland.

Journal of the Endocrine Society
|March 30, 2018
PubMed

Insights

Children born small for gestational age (SGA) have higher inflammation markers, while those born large for gestational age (LGA) have lower levels. This suggests SGA children may face greater future metabolic risks.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Health
  • Inflammation Research

Background:

  • Birth size is linked to future cardiometabolic risk, often mediated by low-grade inflammation.
  • Interleukin-1 receptor antagonist (IL-1ra) is a key inflammatory marker.

Purpose of the Study:

  • To investigate plasma IL-1ra levels in relation to birth size (SGA, appropriate, LGA) in prepubertal children.
  • To examine associations between IL-1ra and cardiometabolic/inflammatory markers.

Main Methods:

  • A cohort study involving 5-8 year old children categorized by birth size (SGA, n=23; appropriate, n=56; LGA, n=49).
  • Collected anthropometric data and analyzed plasma IL-1ra, alanine transaminase, lipids, glucose, 25-hydroxyvitamin D, and high-sensitivity C-reactive protein (hs-CRP).

Main Results:

  • Plasma IL-1ra concentrations, adjusted for BMI SDS, were highest in SGA-born and lowest in LGA-born children (P=0.015).
  • IL-1ra showed strong associations with BMI SDS (P<0.001) and hs-CRP (P<0.001), even after BMI adjustment.

Conclusions:

  • Prepubertal SGA children exhibited higher IL-1ra levels, while LGA children had lower levels.
  • The strong association between IL-1ra and hs-CRP, independent of BMI, suggests a heightened inflammatory state in SGA children.
  • SGA children may be at increased risk for later metabolic disturbances due to this inflammatory profile.
Abstract

Keywords:
birth sizecardiometabolic riskcatch-up growthlarge for gestational agelow-grade inflammationsmall for gestational age

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