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Ene cyclization reaction in heterocycle synthesis
1Department of Chemistry, Tripura University (A Central University), Suryamaninagar 799022, India. pipas2010@gmail.com.
Organic & Biomolecular Chemistry
|March 30, 2018
Summary
Ene cyclization is a versatile synthetic method for creating diverse heterocyclic compounds. This review details its applications in synthesizing oxygen, nitrogen, and sulfur heterocycles, including natural product synthesis.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
Background:
- Ene cyclization is a key reaction in organic synthesis.
- Oxonium, iminium, and thionium ion intermediates are versatile in ene cyclization.
- This reaction offers high regio- and stereoselectivity.
Purpose of the Study:
- To review the synthetic utilities of ene cyclization reactions.
- To cover the synthesis of various ring sizes of oxygen, nitrogen, and sulfur heterocycles.
- To discuss applications in natural product synthesis.
Main Methods:
- Literature review of ene cyclization reactions from 1986 to 2017.
- Discussion of reaction mechanisms where relevant.
- Analysis of synthetic scope and utility.
Main Results:
- Ene cyclization is an indispensable tool for synthesizing diverse heterocyclic compounds.
- The reaction's ease of control over regio- and stereoselectivity enables novel compound development.
- Numerous applications in synthesizing oxygen, nitrogen, and sulfur heterocycles were identified.
Conclusions:
- Ene cyclization is a powerful and adaptable method for heterocyclic synthesis.
- Its application extends to the construction of complex natural products.
- The review highlights the reaction's significance in modern organic chemistry.
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