Related Experiment Video
Updated: Feb 12, 2026
10:45
Isolation of Human Myoblasts, Assessment of Myogenic Differentiation, and Store-operated Calcium Entry Measurement
Published on: July 26, 2017
10.7K
Store-Operated Calcium Entry: An Historical Overview
1Scientist Emeritus, National Institute of Environmental Health Sciences - NIH, Research Triangle Park, NC, USA. putney@niehs.nih.gov.
Advances in Experimental Medicine and Biology
|March 30, 2018
Summary
Store-operated calcium entry, a key calcium (Ca2+) signaling pathway, has progressed from concept to molecular understanding over 30 years. This overview highlights major advancements in its mechanisms and regulation.
Area of Science:
- Cellular Biology
- Biochemistry
- Physiology
Background:
- Store-operated calcium entry (SOCE) is a fundamental calcium (Ca2+) influx mechanism crucial for cellular signaling.
- Understanding SOCE has evolved significantly over three decades, transitioning from theoretical models to detailed molecular insights.
Observation:
- The STIM and ORAI proteins are central to the molecular machinery of SOCE.
- Dynamic interactions between ER calcium sensors and plasma membrane channels govern calcium entry.
Findings:
- Key milestones in SOCE research include the identification of STIM proteins as calcium sensors in the endoplasmic reticulum and ORAI proteins as pore-forming subunits of the calcium release-activated calcium channel (CRAC) channel.
- The elucidation of the STIM-ORAI interaction mechanism provides a molecular basis for store-operated calcium entry.
Implications:
- Understanding SOCE mechanisms and regulation is vital for numerous physiological processes, including immune responses, muscle contraction, and neuronal activity.
- Dysregulation of SOCE is implicated in various human diseases, highlighting its therapeutic potential.
- Further research into SOCE regulation may uncover novel therapeutic targets for calcium-related disorders.
Keywords:
Calcium channelsCalcium signalingHistoryIntracellular calcium storesSignaling mechanismsStore-operated channelsMore Related Videos
14:18Fluorescence-based Measurement of Store-operated Calcium Entry in Live Cells: from Cultured Cancer Cell to Skeletal Muscle Fiber
Published on: February 13, 2012
21.8K
06:34Operation of a 25 KWth Calcium Looping Pilot-plant with High Oxygen Concentrations in the Calciner
Published on: October 25, 2017
8.4K
Related Concept Videos
01:12Energy Stored in a Capacitor
4.8K
When an archer pulls the string in a bow, he saves the work done in the form of elastic potential energy. When he releases the string, the potential energy is released as kinetic energy of the arrow. A capacitor works on the same principle in which the work done is saved as electric potential energy. The potential energy (UC) could be calculated by measuring the work done (W) to charge the capacitor.
4.8K
01:10Energy Stored in Capacitors
1.1K
A parallel plate capacitor, when connected to a battery, develops a potential difference across its plates. This potential difference is key to the operation of the capacitor, as it determines how much electrical energy the capacitor can store.
By integrating the equation that relates voltage and current in a capacitor, one can derive an equation for the voltage across the capacitor at any given time. This equation is crucial in understanding and predicting the behavior of capacitors in...
By integrating the equation that relates voltage and current in a capacitor, one can derive an equation for the voltage across the capacitor at any given time. This equation is crucial in understanding and predicting the behavior of capacitors in...
1.1K
01:16Energy Stored in Inductors
964
An inductor is ingeniously crafted to accumulate energy within its magnetic field. This field is a direct result of the current that meanders through its coiled structure. When this current maintains a steady state, there is no detectable voltage across the inductor, prompting it to mimic the behavior of a short circuit when faced with direct current.
In terms of gauging the energy stored within an inductor, it is equivalent to the integral of the power delivered at every individual moment, all...
In terms of gauging the energy stored within an inductor, it is equivalent to the integral of the power delivered at every individual moment, all...
964
01:26Energy Stored in a Capacitor: Problem Solving
1.8K
In 1749, Benjamin Franklin coined the word battery for a series of capacitors connected to store energy. Capacitors store electric potential energy that can be released over a short time. This property means capacitors have a wide range of applications.
Capacitor-discharge ignition is a type of ignition system commonly found in small engines where the energy released from a capacitor ignites an induction coil that, in turn, fires the spark plug.
To calculate the energy stored in a capacitor of...
Capacitor-discharge ignition is a type of ignition system commonly found in small engines where the energy released from a capacitor ignites an induction coil that, in turn, fires the spark plug.
To calculate the energy stored in a capacitor of...
1.8K
01:31Energy Stored In A Coaxial Cable
2.1K
A coaxial cable consists of a central copper conductor used for transmitting signals, followed by an insulator shield, a metallic braided mesh that prevents signal interference, and a plastic layer that encases the entire assembly.
In the simplest form, a coaxial cable can be represented by two long hollow concentric cylinders in which the current flows in opposite directions. The magnetic field inside and outside the coaxial cable is determined by using Ampère's law. The magnetic field inside...
In the simplest form, a coaxial cable can be represented by two long hollow concentric cylinders in which the current flows in opposite directions. The magnetic field inside and outside the coaxial cable is determined by using Ampère's law. The magnetic field inside...
2.1K
01:27Real Number Operations
343
The concept of real numbers includes all the values that can be represented on a continuous number line. The system began with basic counting values used for enumeration. It later expanded to include values that represent the absence of quantity and opposites of the counting values. When situations required expressing parts of a whole or dividing quantities evenly, values capable of representing such proportions were developed. When written using decimal notation, these values can end or repeat...
343