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A new semisynthetic ergot peptide alkaloid: DCN 203-922
R K Giger1, H R Loosli, M D Walkinshaw
1Preclinical Research, Sandoz Ltd., Basel, Switzerland.
Abstract:
We report the synthesis, stereochemistry and preliminary pharmacological evaluation of DCN 203-922, a novel ergot alkaloid of the cyclol type, which contains in its peptide moiety the uncommon amino acid L-allo-isoleucine.