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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Sinulaspirolactam A, a novel aza-spirocyclic valerenane sesquiterpenoid from soft coral Sinularia sp
Wei Lai1, Sheng-Ying Qin2, Ge Zou1
1a Department of Chemistry, College of Chemistry and Materials Science , Jinan University , Guangzhou 510632 , China.
Abstract:
A novel valerenane sesquiterpenoid sinulaspirolactam A (1), together with five known compounds, was isolated from the soft coral Sinularia sp. Their structures were determined by spectroscopic analyses. The absolute configuration of 1 was established by ECD calculation. Compound 1 was the first example of valerenane sesquiterpenoid bearing an aza-spiro[4.5] ring moiety, the plausible biogenetic pathway of which was proposed. Cytotoxic activities of these compounds were also evaluated.
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