Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

1.1K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.1K
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

234
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
234
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

485
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
485
Renal Corpuscle01:20

Renal Corpuscle

7.6K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
7.6K
Renal Clearance01:23

Renal Clearance

2.8K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
2.8K
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

632
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
632

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current oxygen management in mechanically ventilated patients: a prospective observational cohort study.

Journal of critical care·2013
Same author

Clinical review: early patient mobilization in the ICU.

Critical care (London, England)·2013
Same author

Clinical review: the role of the intensivist and the rapid response team in nosocomial end-of-life care.

Critical care (London, England)·2013
Same author

Urinalysis and pre-renal acute kidney injury: time to move on.

Critical care (London, England)·2013
Same author

Prophylactic perioperative sodium bicarbonate to prevent acute kidney injury following open heart surgery: a multicenter double-blinded randomized controlled trial.

PLoS medicine·2013
Same author

Cognitive changes after saline or plasmalyte infusion in healthy volunteers: a multiple blinded, randomized, cross-over trial.

Anesthesiology·2013
Same journal

Adsorption of Pathogens and Blockade of Sepsis Cascade.

Contributions to nephrology·2023
Same journal

Hemoadsorption: Research Agenda and Potential Future Applications.

Contributions to nephrology·2023
Same journal

Hemoperfusion in Poisoning and Drug Overdose.

Contributions to nephrology·2023
Same journal

Hemoperfusion in Burns.

Contributions to nephrology·2023
Same journal

Sequential Extracorporeal Therapy in Sepsis.

Contributions to nephrology·2023
Same journal

The Use of Adsorption in Extracorporeal Liver Support: The Double Plasma Molecular Adsorption System (DPMAS).

Contributions to nephrology·2023
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

Direct Drug Delivery to Kidney via the Renal Artery
11:18

Direct Drug Delivery to Kidney via the Renal Artery

Published on: April 17, 2021

8.3K

Extra-Renal Indications for Continuous Renal Replacement Therapy.

Suvi T Vaara, Rinaldo Bellomo

    Contributions to Nephrology
    |March 30, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Continuous renal replacement therapy (CRRT) is not recommended for immunomodulation based on recent trials. However, CRRT remains valuable for fluid removal, toxin clearance, and managing lactic acidosis in critically ill patients.

    More Related Videos

    Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats
    05:09

    Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats

    Published on: February 8, 2022

    3.0K
    Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
    06:38

    Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

    Published on: March 11, 2016

    12.6K

    Related Experiment Videos

    Last Updated: Feb 12, 2026

    Direct Drug Delivery to Kidney via the Renal Artery
    11:18

    Direct Drug Delivery to Kidney via the Renal Artery

    Published on: April 17, 2021

    8.3K
    Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats
    05:09

    Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats

    Published on: February 8, 2022

    3.0K
    Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
    06:38

    Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

    Published on: March 11, 2016

    12.6K

    Area of Science:

    • Nephrology
    • Intensive Care Medicine

    Background:

    • Continuous renal replacement therapy (CRRT) offers benefits beyond uremic toxin removal, including middle-molecule clearance and suitability for hemodynamically unstable patients.
    • Historically, CRRT was frequently used for immunomodulation by removing plasma cytokines, generating significant clinical interest.

    Purpose of the Study:

    • To evaluate the efficacy of CRRT for immunomodulation.
    • To delineate current, evidence-based indications for CRRT.

    Main Methods:

    • Review of recent randomized controlled trials investigating CRRT for immunomodulation.
    • Analysis of established and emerging indications for CRRT in critically ill patients.

    Main Results:

    • Recent randomized controlled trials have yielded discouraging results regarding CRRT's efficacy for immunomodulation.
    • CRRT is not recommended for immunomodulation.
    • Established indications include fluid removal in overloaded patients and removal of specific toxins (e.g., ammonia, myoglobin).

    Conclusions:

    • CRRT is not indicated for immunomodulation.
    • Current CRRT indications focus on fluid management, toxin removal (including metformin-associated lactic acidosis), and supportive care in specific critical conditions like tumor lysis syndrome.