Related Experiment Video
Updated: Aug 31, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
Applications of pulsed Doppler flow mapping to left sided cardiac valvular lesions
D Kalmanson1, C Veyrat, C Gourtchiglouian
1Département de Cardiologie, Fondation A. de Rothschild, Paris, France.
Insights
Flow mapping is a new echocardiography technique that diagnoses, assesses severity, and identifies the site of valvular heart disease lesions. This method aids in differentiating various valve issues and measuring leak sizes.
Area of Science:
- Cardiology
- Echocardiography
- Medical Imaging
Background:
- Standard pulsed Doppler focuses on velocity calibration.
- Flow mapping, developed recently, targets flow signals at lesion sites.
- This technique offers a distinct approach to evaluating valvular heart disease.
Purpose of the Study:
- To review the diagnostic capabilities of flow mapping in valvular heart disease.
- To highlight the technique's role in diagnosing, assessing severity, and locating lesions.
- To demonstrate its application in differentiating specific valve pathologies.
Main Methods:
- Utilized invasive correlations in 267 valvular heart disease cases.
- Employed flow mapping to detect flow anomalies, assess spatial signal spread, and analyze jet direction.
- Incorporated selection of 2D short axis planes and 3D approaches for jet analysis.
Main Results:
- Flow mapping successfully diagnosed lesions based on flow anomalies.
- Severity assessment was achieved by analyzing the spatial spread of flow signals.
- Accurate lesion site identification was possible through anatomical location and jet direction analysis.
- Differentiated cusp tears from bioprosthetic leaks and measured leak sizes.
Conclusions:
- Flow mapping is effective for diagnosing and characterizing valvular heart disease lesions.
- The technique provides precise localization and severity assessment of valve abnormalities.
- Optimal results depend on appropriate methodology, including 2D and 3D imaging approaches.
Abstract:
The flow mapping procedure has been developed in parallel to the standard pulsed Doppler procedure. It has a different purpose--picking up flow signals at the site of lesions rather than calibrating velocities--and has its own methodology, developed within the last six years. On the basis of invasive correlations performed in 267 cases of valvular heart disease, we review the three-fold purpose of the flow mapping technique: diagnosing lesions, relying on the presence of flow anomalies; assessing their severity, relying on the spatial spreading of these flow signals; and identifying the site of the lesion, which is a specific advantage, relying on the anatomical location of these flow signals and/or on the direction of the jets. For example, using this technique, it is now possible to easily differentiate a cusp tear from a leak of a bioprosthesis, to measure the size of the leaks, and to reconstruct the image of aortic or mitral stenotic areas. These optimal results are only obtained using an appropriate methodology which mainly includes a) the selection of adequate two-dimensional short axis planes in order to explore the diseased valve in its entirety, because of frequent assymetrical orifices, and to pick up the jets at their starting point, b) measurements of the abnormal areas, c) when jets are studied, a three dimensional approach is required in order to cope with the three dimensional nature of the jet and to make available the calculation of three dimensional indices of severity.(ABSTRACT TRUNCATED AT 250 WORDS)
Related Concept Videos
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Cardiac Catheterization III: Left Heart Catheterization
Mitral Stenosis I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests

