Palladium-Catalyzed Hydrocarbonylative C-N Coupling of Alkenes with Amides
Xibing Zhou1, Guoying Zhang1, Bao Gao1
1Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis , University of Science and Technology of China, Chinese Academy of Sciences , Hefei , 230026 , People's Republic of China.
Abstract:
An efficient palladium-catalyzed hydrocarbonylative C-N coupling of alkenes with amides has been developed. The reaction was performed via hydrocarbonylation of alkenes, followed by acyl metathesis with amides. Both intermolecular and intramolecular reactions proceed smoothly to give either branched or linear amides in high turnover number (3500) with NH4Cl or NMP·HCl as a proton source under the palladium catalysis. This reaction offers a catalytic convenient approach to deuterated amides when inexpensive NMP·DCl served as a deuterium source.
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