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Masked hypertension, where blood pressure is normal in clinic but high outside, may increase chronic kidney disease risk in African-Americans. Further research is needed to confirm this association.

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Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Clinic-measured hypertension is linked to kidney function decline and chronic kidney disease (CKD).
  • The association between out-of-clinic hypertension (masked hypertension) and kidney outcomes is not well understood.

Purpose of the Study:

  • To investigate the association of masked hypertension with rapid kidney function decline (RKFD) and incident CKD in African-Americans.

Main Methods:

  • The Jackson Heart Study enrolled 676 African-Americans with clinic BP <140/90 mmHg.
  • Ambulatory BP monitoring defined masked hypertension (e.g., daytime SBP/DBP ≥135/85 mmHg).
  • RKFD and incident CKD were tracked over 8 years using eGFR changes.

Main Results:

  • Over half (52.7%) had masked hypertension.
  • Masked hypertension showed a trend towards increased odds of incident CKD, particularly before propensity score adjustment.
  • No significant association was found between masked hypertension and RKFD.

Conclusions:

  • Masked hypertension may be associated with CKD development in African-Americans.
  • The association requires further investigation, especially after accounting for confounding factors.