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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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[Primary breast synovial sarcoma].

Clara Alfaro-Cervelló1, Octavio Burgués1

  • 1Servicio de Anatomía Patológica, Hospital Clínico Universitario de Valencia, Valencia, España.

Revista Espanola De Patologia : Publicacion Oficial De La Sociedad Espanola De Anatomia Patologica Y De La Sociedad Espanola De Citologia
|April 1, 2018
PubMed
Summary
This summary is machine-generated.

Primary breast synovial sarcoma is exceptionally rare. This case report details a patient diagnosed with this unusual spindle cell neoplasm, confirmed by molecular genetics.

Keywords:
Breast neoplasmsNeoplasias de mamaPrimary breast sarcomaSarcoma sinovialSarcomas primarios de mamaSynovial sarcoma

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Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Primary synovial sarcoma of the breast is an exceedingly rare diagnosis.
  • This report focuses on a unique case in a patient with a history of breast carcinoma.

Observation:

  • A 33-year-old woman presented with a hypercellular breast lesion.
  • Histopathology revealed spindle cells with distinct storiform and herringbone patterns.
  • Immunohistochemistry showed characteristic markers including vimentin and CD99.

Findings:

  • Molecular analysis confirmed the SS18-SSX fusion gene, indicative of the t(X;18)(p11.2;q11.2) translocation.
  • This genetic finding definitively diagnosed the tumor as synovial sarcoma.
  • The patient had a prior diagnosis of fusocellular breast carcinoma.

Implications:

  • Highlights the importance of molecular diagnostics in rare breast tumors.
  • Contributes to the understanding of primary breast synovial sarcoma.
  • Emphasizes the need for differential diagnosis in spindle cell breast lesions.