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Related Concept Videos

Residual Stresses01:26

Residual Stresses

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Residual stresses reside in a structure even after removing the original stress inducer. This phenomenon often arises from varied plastic deformations across different parts of a structure. Consider a rod stretched beyond its yield point. It will not regain its original length due to permanent deformation. Even after load removal, the rod does not entirely lose stress because of uneven plastic deformations, resulting in residual stresses. The computation of these stresses in structures is...
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A residual plot is a statistical representation of data used to analyze correlation and regression results. It helps verify the requirements for drawing specific conclusions about correlation and regression. To obtain the residual plot, first, the residual for each data value is calculated, which is simply the vertical distance between the observed and the predicted value obtained from the regression equation.
When the residual values are plotted against the variable x, it is called a residual...
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Finding the Center of Gravity01:03

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The center of gravity of a body is an imaginary point where the body's total weight is assumed to be concentrated, and the body is perfectly balanced. The center of the mass of a body is a point at which the whole of the mass of the body appears to be concentrated. If the acceleration due to gravity, g, has the same value at all points on a body, its center of gravity is identical to its center of mass. The center of gravity of homogeneous bodies such as a sphere, cube, or rectangular plate...
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Residual Stresses in Circular Shafts01:10

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In materials that exhibit elastic and plastic behavior, known as elastoplastic materials, residual stresses can accumulate when these materials experience plastic deformation. This deformation arises from either high levels of shearing stress or significant strains. Residual stresses are internal stresses that persist within a material after removing the external force causing deformation. This phenomenon is demonstrated when observing the behavior of a shaft under torque; notably, the...
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Respiratory System Abnormal Finding I: Inspection and Percussion01:30

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Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
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Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

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In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
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Finding More in Less: Precision Medicine for Pancreatic Cancer Using Residual Cytology Samples.

Raquel Antón-Peñalver1, María Ortega2, Jose Francisco González-Muñoz2

  • 1Departament de Patologia, Facultat de Medicina i Odontologia, Universitat de València, València, Spain.

Cytopathology : Official Journal of the British Society for Clinical Cytology
|January 26, 2026
PubMed
Summary

Residual liquid-based cytology (LBC) from pancreatic ductal adenocarcinoma (PDAC) is suitable for molecular analysis, even after long-term storage. Preserving these samples ensures patients can access targeted therapies.

Keywords:
cell blockliquid‐based cytologymicrosatellite instabilitynext‐generation sequencingpancreatic adenocarcinoma

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Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Gastroenterology

Background:

  • Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with increasing incidence.
  • Accurate diagnosis relies on pathological confirmation, often via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA).
  • The utility of residual liquid-based cytology (LBC) samples for PDAC molecular testing is not well-established.

Purpose of the Study:

  • To evaluate the utility and storage conditions of residual LBC samples for molecular analysis in PDAC.
  • To determine if residual LBC can be reliably used for next-generation sequencing (NGS) and other molecular tests.
  • To assess the impact of storage time on the quality of nucleic acids from LBC samples.

Main Methods:

  • Retrospective analysis of 268 PDAC patients diagnosed via EUS-FNA and LBC from 2020-2024.
  • Residual LBC samples were stored, and molecular analyses were performed based on availability and quality.
  • Comparison of DNA and RNA quality and test validity between residual LBC and cell blocks.

Main Results:

  • Residual LBC was the sole available sample for 8 patients.
  • DNA concentration was higher and median absolute pairwise difference (MAPD) was lower in LBC compared to cell blocks.
  • LBC storage time did not compromise NGS validity, with comparable results to cell blocks for DNA and MSI RT-PCR.
  • RNA analysis yielded fewer valid studies, with no significant difference between LBC and cell blocks.

Conclusions:

  • Residual LBC samples from PDAC are valid for molecular analysis, maintaining nucleic acid quality.
  • Residual LBC can serve as the primary or sole sample for molecular testing.
  • Preservation of residual LBC is crucial for ensuring patient access to essential targeted therapies.