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Related Experiment Video

Updated: Jul 17, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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Published on: January 20, 2019

Plasma Cells in Pleural Effusion.

Marco P Barros Pinto^1,2

¹Hospital Santa Maria - Unidade Local de Saúde Santa Maria, Lisbon, Portugal.

Cytopathology : Official Journal of the British Society for Clinical Cytology

|July 16, 2026

Summary

Myelomatous pleural effusion (MPE) is a rare complication in multiple myeloma (MM) patients, signaling advanced disease. Early detection of MPE is vital for improving patient outcomes and treatment strategies.

Keywords:

multiple myeloma myelomatous pleural effusion plasma cells

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Area of Science:

Oncology
Pulmonary Medicine

Background:

Myelomatous pleural effusion (MPE) is an uncommon manifestation of multiple myeloma (MM).
MPE signifies advanced-stage MM and is associated with a poor prognosis, typically less than 4 months survival.
The rarity and poor prognosis underscore the need for timely diagnosis.

Purpose of the Study:

To highlight the significance of early detection of myelomatous pleural effusion (MPE) in multiple myeloma (MM).
To emphasize the prognostic implications of MPE in MM patients.
To inform clinical strategies for optimizing treatment upon MPE diagnosis.

Main Methods:

Literature review on MPE in multiple myeloma.
Analysis of prognostic factors associated with MPE.
Review of diagnostic approaches for MPE.

Main Results:

MPE occurs in less than 1% of multiple myeloma patients.
MPE is a marker of advanced disease.
Survival is significantly limited in patients with MPE.

Conclusions:

Early identification of MPE is critical for MM management.
Prompt diagnosis can lead to optimized therapeutic interventions.
Recognizing MPE's prognostic impact is essential for patient care.